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If you experience worsening depression, increased suicidal thoughts, or new psychiatric symptoms after starting semaglutide, contact your mental health provider immediatelysuch changes warrant urgent evaluation

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Moreover, there is a need for additional studies that identify patients or sub-types of patients with various addictions who might benefit from treatment with such medications: for instance, the possibility that polymorphisms in the GLP-1R genes influence the treatment outcome of GLP-1R agonists on alcohol drinking in patients with AUD