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This is especially true when the headache complaints are not accompanied by the typical features of migraine such as nausea, light/sound sensitivity, and exacerbation upon physical activity (Cutrer 2012)

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Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation

Single-cell transcriptomic profiling of CTCs collected during resting phases reveals elevated mitotic activity, providing a mechanistic basis for time-dependent metastatic potential and underscoring the importance of chronobiology in cancer diagnosis and therapy (176)