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While orforglipron has shown in studies to be slightly more effective at reducing body weight and reducing blood sugar levels than semaglutide, Orforglipron showed higher rates of adverse side effects such as nausea, vomiting and other gastrointestinal issues compared with semaglutide

Moreover, HMGB1 passively released from necrotic cells, binds to toll-like receptor 4 (TLR4) on DCs, facilitates their maturation and the effective presentation of tumor antigens to T cells

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By mimicking the GLP-1 hormone, Ozempic can decrease appetite, reduce food intake, and ultimately help manage body weight effectively