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10.1016/j.bbabio.2010.03.005 Biochim

But poor or inconsistent sleep can increase stress hormones, such as cortisol, which promote fat retention and hinder weight loss

Changes in Insulin Regimen Including Changes to Administration Site Changes in an insulin regimen (e.g., insulin strength, manufacturer, type, injection site, or method of administration) may affect glycemic control and predispose to hypoglycemia [see Warnings and Precautions (5.3)] or hyperglycemia