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Roux-en-Y gastric bypass surgery (RYGB) but not sleeve gastric bypass surgery or gastric banding, increases the risk of vitamin B 12 deficiency and requires preventive post-operative treatment with either injected or high-dose oral supplementation

In addition, pegilodecakin, a long-acting recombinant pegylated IL-10, has been evaluated in dose escalation/expansion study in patients with advanced solid tumors as a monotherapy or combination with other anticancer drugs in a phase I trial (NCT02009449)

SC Injection: 5mg/mL, 10mg/mL solution

As a result, more studies are warranted to explore the potential benefits of high serum levels or intake of vitamin B12 on sleep quality