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The hepatotoxicity of APAP rests predominantly with the highly toxic and reactive compound NAPQI, which forms covalent bonds with sulfhydryl groups on cysteine and lysine molecules within the mitochondria of hepatocytes and which spontaneously reacts with GSH and binds to hepatic proteins

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Consequently, detectability in the context of standard testing is low

On average, the treated individuals gained an average of 4.6 pounds of lean body mass, and they shed a similar amount of body fat. In other words, they were well on their way to the Liver King physique