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A positive influence of L-carnitine treatment in people with genetically determined ASD was described in the review of Malaguarnera and Cauli [129]

The results indicated a reduction in both gray and white matter regions after 1 year in the brains of patients who underwent chemotherapy, establishing a clear connection between white matter integrity, cognitive impairment, and chemotherapy ( Moreover, paclitaxel has been linked to detrimental effects on white matter integrity in the CNS

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44 The 52-week data from 966 patients with MASH and F1B, F2, or F3 fibrosis in the MAESTRO-NASH trial revealed significant effects of resmetirom on MASH resolution, fibrosis improvement, and LDL cholesterol reduction (NCT03900429), 77 forming the basis for potential FDA approval of resmetirom for MASH treatment