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Description

GCLC knockout mice die within a month of birth due to the absence of hepatic GSH synthesis

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Certain medical conditions, such as cancer, HIV/AIDS, type 2 diabetes, hepatitis, and Parkinsons disease, can also deplete glutathione levels

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Methods: We developed a 3D in vitro model of ALGS by generating liver organoids from human induced pluripotent stem cells (iPSC)

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The antioxidant neutralizes toxins and supports cell renewal

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