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Keywords: N-acetylcysteine, Fatty liver disease, Hepatic steatosis, Metabolic dysfunction, Metabolic profile, Clinical trial Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD), is defined as fat accumulation in more than 5% of liver cells when other risk factors for fat accumulation, such as alcohol or drugs, have been ruled out

reported that IRI-induced AKI mice with gut dysbiosis exhibited reduced SCFA levels and impaired metabolic activity in the renal tubular epithelial cells, which collectively promoted CKD development and renal fibrosis [169]

b , Differential gene score of the CRISPR screens from iER-GshF HEK293T cells cultured with 1 g/ml doxycycline compared to untreated