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When NNMT methylates nicotinamide, it creates a compound called 1-methylnicotinamide

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ISBN 978-1-315-11954-0

This enables Cagri to form conserved interactions when bound to CTR and AMYRs, including the inter-peptide contacts that facilitate the formation and stabilisation of the bypass motif and the intramolecular salt bridge (E14 Cagri and R17 Cagri )