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Retatrutide itself is a synthetic peptide studied within metabolic and endocrine research

The clinical trial evidence indicates that tirzepatide is associated with better glycemic control and weight reduction than the conventional GLP-1 monotherapy, with the SURPASS clinical trial program being associated with HbA1c changes of up to 2.4% compared to baseline and weight reduction of more than 22% of the baseline weight at the highest dosage