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Data from the MILES trial indicate that metformin modified multiple pathways associated with aging including metabolic pathways, collagen trimerization and extracellular matrix (ECM) remodeling, adipose tissue and fatty acid metabolism, mitochondria, and the MutS genes, MSH2 and MSH3, which play a role in DNA mismatch repair, a process that declines with age (79)

Modest, not dramatic, and attributable in part to the improved recovery, allowing more consistent training volume

It is used in research to study growth hormone signaling and peptide interactions

Documentation should include the specific cancer type when known, as this distinction is clinically significant