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Anyone suspecting B12 deficiency especially with neurological symptoms should seek GP review promptly rather than self-treating with over-the-counter supplements

Whilst blood in stool is not a recognised adverse reaction in the MHRA-approved Summary of Product Characteristics, patients may experience gastrointestinal side effectssuch as constipationthat can indirectly contribute to rectal bleeding

The gender-specific effect of ibuprofen in our study suggests that ibuprofen has more pronounced effect on female livers as higher 17-HSD2 expression indicate more accumulation of sex hormone in females that will eventually lead to perturbed energy metabolism pathways