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Possible Side Effects Mild side effects of Vitamin B12 may include: ( 12 ) Mild pain, itching, or swelling at the injection site Temporary nausea or headache Mild diarrhea Hot flashes Vomiting These side effects do not affect all patients and are generally temporary and mild While rare, more serious side effects of Vitamin B12 injections can include ( 12 ): Irregular heartbeat Heart palpitations Hives or skin rash If you notice any severe reactions to a Vitamin B12 shot, contact a medical professional immediately

There can be an immediate solution, along with its modulatory controlling effect described above for VEGF (see above, Section 2.3 and Section 2.4), as the promoter of the egr-1 gene also mediates angiogenesis [158,159] and induces cytokine and growth factor generation and early extracellular matrix (collagen) formation

Systemic lupus erythematosus (SLE) and rheumatoid arthritis have been noted in case reports