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In some embodiments, the otic formulation or composition comprises about 6% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

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doi:10.1016/j.aprim.2021.102074 4

Moreover, no studies have been undertaken in controlled circumstances to demonstrate whether a reduction in sulphotransferase activity causes increased paracetamol oxidation or increased propensity to paracetamol toxicity at either therapeutic or supra-therapeutic doses