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Semaglutide stimulates glucose-dependent insulin secretion, meaning it triggers insulin release when blood glucose is elevated but does not cause problematic hypoglycemia in people without diabetes because it stops working when glucose normalizes

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These include semaglutide (Wegovy) and liraglutide (Saxenda), along with newer combination agents like tirzepatide (Zepbound), which targets both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors