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Because of this, Eli Lillys own prescribing information for Mounjaro and Zepbound tells patients to use a barrier method of birth control, or switch to a nonoral method, for four weeks after starting the drug and for four weeks after every dose increase (Mounjaro prescribing information)

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Heparanase regulates the M1 polarization of renal macrophages and their crosstalk with renal epithelial tubular cells after ischemia/reperfusion injury