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Preclinical studies have revealed their ability to reduce neuroinflammation, reduce tau phosphorylation, reduce amyloid deposition, and improve memory formation, all of which are implicated in the progression of neurodegeneration

Research has also evaluated creatine supplementation for post-exercise recovery, thermoregulation, rehabilitation, neuroprotection, and overall exercise performance

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The second (clinical) problem is the lack of clarity in defining the clinical concept of AD, which is increasingly being discussed by the most visionary neurologists