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Further, overall medication requirements dropped, with 43% of the patients discontinuing between one and three drugs

570,571 For example, based on the unique mechanism of action of ASOs, the main safety issues are severe hepatotoxicity and nephrotoxicity caused by drug accumulation

Genetic variation in GLP-1 receptor structure (rs6923761), GLP-dependent insulinotropic polypeptide signaling (GIPR rs1800437), and metabolic regulators like FTO (rs9939609) influence both drug efficacy and side effect severity