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Consistent with this idea, subdiaphragmatic vagal deafferentation 44 and selective knock-down of Glp1r in the nodose ganglion 45 have been shown to impair peripheral GLP1R-agonist induced reduction of food intake in rats

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The researchers did outline several of the studys limitations, stating additional adjustments for potential confounders, such as alcohol or substance misuse, were limited by the relatively small number of reports found