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As fumarate is further metabolized into malate and then oxaloacetate, it facilitates the production of NADH and FADH2crucial electron carriers that feed directly into the electron transport chain to maximize ATP synthesis

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In addition to the stimulators, activation of TRPV4 in neurons by oxidative stress such as H 2 O 2 was reported (Materazzi et al., 1)

It is important to follow the prescribed dosage and not exceed the recommended intake