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Circulation of the BAs is highly dependent on transporting from the hepatocytes into biliary tracts, a process that is highly susceptible to perturbation from even minor liver damage indicating that they may be sensitive biomarkers of liver injury (Yamazaki et al
Cost note: At 2-5 mg/kg for a 75 kg individual (150-375 mg per injection), FOXO4-DRI becomes one of the most expensive peptide protocols due to both the high dose and D-amino acid synthesis costs
Regulatory status can change slowly
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