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Expression of -glutamylcysteine synthetase (-GCS) and multidrug resistance-associated protein (MRP), but not human canalicular multispecific organic anion transporter (cMOAT), genes correlates with exposure of human lung cancers to platinum drugs

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This is attributed to tirzepatides dual-action mechanism, which targets both GLP-1 and GIP metabolic receptors

The data suggest that GLP-1RAs may neutralize the T2D-induced increase in cancer incidence