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Together, these modifications produce a compound with substantially lower systemic plasma clearance than GHRP-6 approximately five-fold lower and moderate resistance to metabolic degradation, resulting in a more sustained and reproducible GH secretory response

While earlier GHRPs like GHRP-6 and GHRP-2 effectively released GH, they also dose-dependently stimulated ACTH and cortisol, with GHRP-2 elevating ACTH to 350% of GHRH levels at maximally effective doses

[DOI] [PMC free article] [PubMed] [Google Scholar] [22].Doherty E, Oaks Z, Perl A

This makes it a practical option in wellness and longevity settings where the goal is controlled recovery support rather than aggressive bodybuilding