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The common gastrointestinal side effects of GLP-1 receptor agonists - nausea, vomiting, diarrhea, constipation - are mediated by the drugs effects on the GI tract and brain, which should be the same regardless of whether the semaglutide or tirzepatide was produced by a commercial manufacturer or a compounding pharmacy

Heart rate changes represent a recognised effect of tirzepatide

The complexion then appears brighter, the skin texture is refined and fine lines are visibly reduced

Long-acting formulations (e.g., liraglutide, dulaglutide and semaglutide) predominantly enhance insulin secretion and suppress glucagon release, leading to sustained glycaemia [37, 38] (Fig