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These processes enhance synaptic plasticity within corticolimbic circuits (hippocampus, medial amygdala, prefrontal cortex)

Chaturvedi, R

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For example, 5-HT engages HTR2A and HTR3A receptors on macrophages, enhancing prostaglandin E (PGE) expression and thereby influencing local immune responses (De Vadder et al., 2018)Indirectly, the ANS regulates gastrointestinal motility and mucus secretion, which alters the physical proximity and duration of bacterialimmune cell interactions, ultimately affecting immune activation