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The selection of the core targets was based on the inclusion criteria being set at double median degree of freedom, median betweenness centrality and median closeness centrality [35]

Factors conferring relative protection to children from the toxic effect of paracetamol overdose include increases in paracetamol sulphation capacity [44,45,46,47,48], relative immaturity of the CYP450 oxidation system [15, 46, 49, 51] and the larger relative liver volume found in children [59] but these theoretical mechanisms have not been confirmed

MDROs (so-called superbugs) that were previously transmitted mainly in the hospital are now being acquired also in community-associated settings and are spreading more in the community [19]