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Subsequently, mice were gavaged with 10 L/gr of a 20% glucose (Sigma-Aldrich) solution in PBS (Biological Industries) and blood glucose was measured at 15 min, 30 min, 45 min, 60 min, 90 min, and 120 min, following glucose oral feeding
What causes this decline
As the primary source of reducing equivalents, NADPH is primarily produced by glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase in the pentose phosphate pathway (PPP)
2017a, b, c)In addition, an aberrant gene expression profile is linked to the mitochondrial phenotype observed in DS, characterized by reduced respiratory efficiency, changes in mitochondrial morphology, altered oxidative metabolism, and impaired mitochondrial biogenesis (Izzo et al
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