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The most commonly reported include: Nausea Reduced appetite Bloating or gas Constipation or diarrhea Mild fatigue, especially during dose changes Mild GI upset Most side effects are temporary and often improve as your body adjusts

It acts as a physiological ligand for Fe 2 + , promoting assembly of iron-sulfur (Fe-S) clusters and biosynthesis of Fe-S proteins, which participate in essential biological functions including electron transfer, the Krebs cycle, maintenance of genome integrity, enzymatic catalysis, and iron homeostasis 15

Wegovy, whilst more effective (average 10-15% weight loss in clinical trials), is reserved for specific circumstances and is only available through NHS specialist Tier 3 weight management services for people meeting specific criteria under TA875, with treatment limited to a maximum of 2 years