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Geetika Arora, an endocrinologist at Northwell's Phelps Hospital, puts it simply: "The trade-off comes down to convenience versus maximum weight loss." In a Lilly-funded trial published by The Lancet, patients on 12 to 36 milligrams of orforglipron lost an average of 15 to 20 pounds, compared with 8 to 11 pounds for those on 7 to 14 milligrams of Rybelsus