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Preclinical models found that GLP-1 RAs reduce intestinal inflammation in dextran sulfate sodium (DSS)-induced colitis, by increasing IL-22 production by colonic IELs and several beneficial bacteria, including Firmicutes, Proteobacteria and Lactobacillus reuteri (93)

While neither the American Urological Association (AUA) nor the European Association of Urology (EAU) explicitly address the testosterone-modulating properties of GLP-1 agonists, both emphasize the relevance of metabolic health in the management of testosterone deficiency

Specific concerns in eating disorder populations warrant consideration

Nevertheless, evidence regarding its effects on muscle mass in the absence of exercise remains inconclusive [50]