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Efficacy In the original phase 3 randomized trials for obesity, average weight reduction compared to placebo has ranged from 5.3% to 17.8% after 56 to 72 wk (Table 1), with improvements in several obesity-related risks and complications [[13], [14], [15]]

These inspections were conducted in multiple areas across the country and aimed to identify violations related to unauthorised sales, improper prescription methods, and deceptive marketing

A positive correlation between mitochondrial fusion-related proteins with mitochondrial content markers was also reported [57]

When patients were stratified by history of cardiovascular disease, the use of the GLP-1 receptor agonist-SGLT-2 inhibitor combination in patients with previous cardiovascular disease was associated with a lower hazard ratio with respect to all cause mortality (0.46, 0.26 to 0.80) than in patients without a history of cardiovascular disease (1.04, 0.64 to 1.71