Microevolution in response to transient heme-iron restriction enhances intracellular bacterial community development and persistence
Metabolic Rewiring: By stopping the conversion of nicotinamide (NAM) into 1-methylnicotinamide (1-MNA), the cell is forced to recycle NAM into NAD+
E-Posters - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION 06.00 - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION - 06.02 - GENETICS, OMICS AND BIOMARKERS P2586 - ESOC25-1678 ATYPICAL PRESENTATIONS IN CADASIL: INTRACRANIAL HAEMORRHAGE AS INDEX PRESENTATION Monturayo Wadzani 1 , Mark Maskery 1 , Amna Sajjad 1 , Mohamed Attia 1 , Ayesha Muneer 1 , Kirsty Ward 1 , Syeda Ismail 1 , Simina Cozma 1 , Dwaipayan Sen 1,2 1 Greater Manchester Comprehensive Stroke Centre, Manchester Centre for Clinical Neurosciences, Northern Care Alliance NHS Foundation Trust, Salford Royal Hospital, Manchester, United Kingdom, 2 Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom Background and Aims: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) caused by pathogenic mutations in NOTCH 3 gene is a leading cause of monogenic cerebral small vessel disease resulting in ischaemic strokes and vascular dementia
Individual responses vary based on genetics, dose, and metabolic factors
