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V.PintatS.FeniciP.et al (2018)

Weight loss via GLP-1s like Ozempic ($17.45B in 2024 sales, up 25% YoY) proved even more lucrative than erectile dysfunction, with Ro's GLP-1 sales 3x'ing between January 2023 and August 2024, pushing topline growth to 66% in 2024 (vs 14% in 2023 and 5% in 2022) and lifting average transaction value from ~$93 to ~$134, while Hims & Hers hit 100K GLP-1 members and ~$343M in annualized GLP-1 revenue by the end of 2024

Concurrent to the pre-clinical studies, the first human study of oxyntomodulin was carried out in a small double-blind placebo-controlled crossover study (31)