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OP successfully prevents increases in arterial ammonia while evidence exists from animal models suggesting a significant decrease in extracellular brain ammonia, preventing intracranial hypertension and improving the mental state (mechanism of action summarized in Fig

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The pharmacology of the native IGF-1 system has been characterized in peer-reviewed studies published in the New England Journal of Medicine , Endocrine Reviews , and other top journals, and the IGF-1 LR3 analog has been characterized in the American Journal of Physiology Endocrinology and Metabolism and Drug Testing and Analysis