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In the AAN/UUO-induced renal fibrosis mouse model and the HK-2/NRK-49F cells treated with AAN, TMP-195 effectively inhibits the expression of HDAC9, attenuates epithelial cell cycle arrest in the G2/M phase, and then reduces the production of pro-fibrotic cytokines and alleviates renal tubulointerstitial fibrosis in mice

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