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Effects of TGF- overexpression via rAAV gene transfer on the early repair processes in an osteochondral defect model in minipigs

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rosea demonstrates neurotrophic capabilities by enhancing the expression of BDNF and facilitating the activation of downstream TrkBCREB signaling pathways, which are essential for synaptic plasticity, neuronal survival, and neurogenesis (56)

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Other notable adverse effects include injection site reactions (for subcutaneous formulations), fatigue, and dizziness

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