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Severe or worsening xerostomia may indicate an underlying condition requiring investigation, such as Sjgren's syndrome, uncontrolled diabetes, or medication interactions that need addressing
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The neurocognitive and neuropsychiatric deficits change CNS immune and glial cells and the negative effect on neuronal pathophysiology is mainly due to myelin homeostasis and plasticity disturbance, hippocampal neurogenesis impairment with neurotoxic astrocyte reactivity (50)
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