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Quick Answer: GLP-1 receptor agonists produce significant reductions in abdominal fat and waist circumference as part of generalized weight loss, though they do not selectively target belly fat

(Eli Lillys pill Foundayo led to the same rate of weight loss in a Phase 3 study that lasted twice as long, but its hard to compare across trials in different phases.) In a separate Phase 2 trial in people with diabetes, called SOLSTICE, patients on the highest dose saw up to a 1.74 percentage-point decrease in a measure of blood sugar called A1C after 26 weeks

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