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43 The relevance of this pathway for tumorigenesis is demonstrated by the fact that humans with the Laron syndrome, a recessively inherited defect in the growth hormone receptor, display extremely low IGF-1 and reduced insulin concentrations and usually do not develop cancer despite high prevalence of obesity and dyslipidemia

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Gupta D, Hull ML, Fraser I, Miller L, Bossuyt PM, Johnson N, et al

The ANOVA did not reveal evidence of a significant treatment interaction between the two groups of mice, F( 3, 24 ) = 0.067