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I started in 12-14 jeans and now Im in a size 4. Tired is a good way to describe my first picture- no energy, tired of my clothes not fitting, tired of trying different diets and them not workingjust tired

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Exogenous administration of FGF21 in DIO in mice show virtually no beneficial effects on glucose tolerance and lipid metabolism, suggesting that the obesity state is FGF21-resistant (240)