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Orthotics help redistribute pressure, but they don't replace the missing cushioning

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Conversely, the Reduction of Cardiovascular Events With Icosapent Ethyl-Intervention Trial (REDUCEIT), which included over 50% of participants with diabetes, demonstrated that daily supplementation with 4 g of icosapent ethyl (a highly purified and stable eicosapentaenoic acid ethyl ester) significantly reduced cardiovascular risk [336]

These can include stomach ulcers, gastritis, and even stomach cancer