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Clearly, SAMes cellular functions are of direct relevance to the prevention of neurodegeneration and its depletion, as seen in the AD central nervous system, would be expected to carry widespread deleterious sequelae

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110 , 111 A meta-analysis of randomized controlled HF trials of 47,662 individuals showed angiotensin II receptor blocker treatment was not found to provide significant benefits in cardiovascular mortality, cardiovascular events, and all-cause mortality