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TUE guidance documents including new regulations on glucocorticoids In order to assist physicians and athletes, WADA will update and publish shortly, on its website, the following guidance documents on managing TUEs to include the new regulations on glucocorticoids: General document on glucocorticoids and TUEs (to be available mid-October 2021) Checklists on a number of medical conditions for which glucocorticoids may be used (to be available early November 2021) TUE Physician Guidelines for TUE Committees on how to evaluate TUE requests for glucocorticoids for different medical conditions (to be available early November 2021) Educational resources In addition to the guidance documents listed above, WADA has provided, or will provide, a number of educational resources as part of its Code Implementation Support Program (CISP), which can be accessed on the Agencys Anti-Doping Education and Learning Platform (ADEL)

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Suitability considerations: Consistent with class precedents for GLP-1-based therapies, retatrutide would not be expected to be suitable during pregnancy or breastfeeding, and paediatric data are currently lacking

Prescription GLP-1 medications like semaglutide work by mimicking GLP-1 structure while resisting enzymatic breakdown