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Example 9 Synthesis of semaglutide: 100mg of compound 4 obtained in example 5 with a purity of about 76.57% was added to an iced freshly prepared 1mL lysate (trifluoroacetic acid: thiobenzylbenzene: triisopropylsilane = 95

These medications may interact with diabetes treatments and may alter the absorption of some oral medicines because they slow stomach emptying

Subsequently, mice with cardiomyocyte-specific (CM-specific) deletion of Glp1r also showed cardioprotective effects of liraglutide in an in vivo model of MI (22), suggesting that the cardioprotective effects of this agent are derived from actions independent of CMs and/or the GLP-1R

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