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Association between global functioning at first schizophrenia diagnosis and treatment resistance

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Beyond the observed increase in female lifespan, we show that pharmacologic blockade of IGF-1R signaling preserves, to various degrees, many aspects of healthspan, including neuromuscular function and endurance, and attenuates the age-related increase in diastolic dysfunction, systemic inflammation, and neoplasias in females

The most common and severe form, infantile or nephropathic cystinosis, constitutes roughly 95% of all cases and is associated with kidney failure at 910 years of age [2]