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GLP-1 Medications and Mental Health: Separating Fact from Fiction Key Points GLP-1 medications do not increase risk of depression, anxiety, or suicidality compared to placebo These medications modestly improve mental health-related quality of life independent of weight loss Emotional eating and food cravings significantly decrease with GLP-1 treatment Psychiatrists should proactively prevent weight gain from psychiatric medications, not just accept it as inevitable GLP-1s may be particularly useful for antipsychotic-induced weight gain, similar to how we already use metformin Side effects are mostly gastrointestinal and manageable with proper dosing and titration Theres been a lot of noise about GLP-1 medications and mental health

Future obesity treatments such as Retatrutide may provide additional support for women facing these challenges

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Weight loss, enhanced insulin sensitivity, and reduction in inflammatory stressors create a physiologic milieu conducive to normal gonadal function