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We thank Olimpia Diadei and Wally Calini for valuable work in monitoring the study, and the staff of the Clinical Research Center and Diabetology Units for contribution to patient care and conducting the study

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In particular, deglutathionylation is mainly catalyzed by glutaredoxins (GRX), denitrosylation by GSH and TRX to some extent, whereas both GRX and TRX seem to be efficient for depersulfidation reactions in addition to disulfide bond reduction (Rouhier et al., 2008