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After administration, 6-OHDA is absorbed into neurons by dopaminergic and noradrenergic transporters due to its structural similarities to dopamine and noradrenaline (Luthman et al., 1989)

MTHFR promotes the synthesis of folate into methylenetetrahydrofolate, which participates in the methionine cycle and gene methylation process [1, 15, 16]

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The NADH and FADH 2 generated during the fat oxidation and acetyl-CoA oxidation in the TCA cycle then can enter the respiratory pathway for the production of ATP via oxidative phosphorylation (Chapter 14)