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FDA approves once-daily oral Wegovy (semaglutide) tablets 25 mg for weight loss and MACE risk reduction in adults with overweight/obesity (OASIS 4: ~17% mean weight loss at 64 weeks vs ~3% with placebo) - Vera Health News

In overweight or obese patients with no history of T2DM, tirzepatide achieved a significant approximately 6 mmHg SBP reduction in the SURMOUNT-1 trial [38]

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Trimethylamine-N-oxide promotes vascular calcification through activation of NLRP3 (Nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome and NF-B (Nuclear factor B) signals